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  • Salud Integral Distributor of AnvirzelTM - HOME || Welcome
    REORDER SUPPLIES Instructions info Payment REQUEST INFO Initial Inquiry Anvirzel First Of Class botanical drug containing oleandrin Proven Science Release tested for Quality Control at FDA approved facilities in the United States ABOUT SALUD INTEGRAL Salud Integral based in Tegucigalpa Honduras provides for distribution and integrates the manufacturing marketing and sales of Anvirzel LEARN MORE ABOUT Anvirzel Anvirzel is a Nerium oleander based product that represents the first of class

    Original URL path: http://www.saludintegral.hn/ (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - COMPANY || About us
    related company in a Class 100 clean room located in Tegucigalpa manufactures Anvirzel Because of the clinical results demonstrated by Anvirzel in Ireland The United States and The Republic of Honduras against many types of cell proliferative disease cancer as well as a spectrum of immune system disorders and viral disease Anvirzel has been approved by the Secretary of Health in Honduras for sale and distribution We would like to

    Original URL path: http://www.saludintegral.hn/company (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - Contact Us
    48 hours of you submitting this form Patient Name Invalid Input Email Invalid Input Address Invalid Input Phone Number Invalid Input Fax Number Invalid Input Overview of Disease State Invalid Input How did you learn about Salud Integral and Anvirzel Select One Friend Family Internet Search Physician Other Please make at least one selection Are you the patient YES NO Please select YES or NO Name of individual making inquiry

    Original URL path: http://www.saludintegral.hn/company/contact (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - ANVIRZEL™ || Product info
    exhibits multiple antitumor activities such as inducing apoptosis reducing molecular mechanisms of cell survival and inhibiting tumor promoting factor bFGF 2 Research Extensive in vitro research has been conducted by leading research institutions in the United States of America One of these institutions has tested ANVIRZEL against a broad spectrum of human malignant cell lines and has demonstrated that ANVIRZEL has inhibitory activity against them In addition to the cancer research being conducted by M D Anderson Cancer Center concurrent research has confirmed that ANVIRZEL has been shown to stimulate the immune system by stimulation of the function and capability of specific subsets of mononuclear cells In addition research has shown that ANVIRZEL specifically stimulates T and B lymphocytes the cell mediated and the humoral mediated immune systems Anvirzel oleanderin has been the subject of numerous prestigious peer reviewed journal publications Is Anvirzel Safe In April 2000 the United States Food and Drug Administration approved a study entitled Phase I Study of ANVIRZEL in Patients With Advanced Solid Tumors was commenced under the direction of Ronald Buckowski M D at Cleveland Clinic in Cleveland Ohio The abstract of their findings was presented at the 2001 annual meeting of the American Society of Clinical Oncology This abstract states ANVIRZEL can be safely administered at doses up to 1 2 ml m2 d 2 4ml by IM administration No dose limiting toxicities were found Continuing clinical safety testing of Nerium oleander based oleandrin products has confirmed additional increased safety parameters Indications Because of its strong cytotoxic effect in combination with an equally strong immunomodulatory effect ANVIRZEL is useful as a therapy both primary and adjuvant for cell proliferative disease cancer certain viral disease and autoimmune inflammatory disease Clinical application of ANVIRZEL in the United States Ireland and Honduras have demonstrated inhibitory activity against various neoplastic disease hepatic disease such as Hepatitis C as well as autoimmune inflammatory disease such as psoriasis The results have been determined both by the clinical practitioner and independent laboratory analysis using PET CT scan MRI and hematological screening Anvirzel has also been used successfully as a combination therapy with various chemotherapeutic agents as well as with radiotherapy International Clinical Experience Using Anvirzel Therapy International clinicians have been treating patients suffering from the above referenced disorders on a compassionate use basis since 1997 Many of these patients were previously diagnosed as terminal These clinicians have experienced a high level of success with disease stabilization partial remission and complete remission almost always accompanied by a very marked improvement in the patients quality of life Observed Side Effects No negative side effects have been reported by clinicians and patients undergoing Anvirzel therapy One case of X ray potentiation while undergoing adjuvant Anvirzel therapy has been reported One case of tachycardia which may or may not be related to use of Anvirzel has been reported Common Thread in Clinical Experience with Anvirzel The Common Thread running through almost all of the clinical records of the patient population using ANVIRZEL has been

    Original URL path: http://www.saludintegral.hn/anvirzel (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - Publications
    Yun Lin BS Peiying Yang PhD Parastoo Azadi PhD Pharmaceutical Development Center University of Texas M D Anderson Cancer Center Houston TX 77030 Abstract Initial identification and characterization of the major biochemical and biological properties of AnvirzelTM a patented hot water extract of Nerium oleander were undertaken using HPLC LC MS and in vitro cell growth inhibition assays Analyses using high pH anion exchange chromatography with electrochemical detection consistently revealed seven major polysaccharide peaks which were subsequently designated as a carbohydrate fingerprint Analyses of monomer sugar composition revealed glucose and galacturonic acid as major carbohydrate residues while carbohydrate linkage studies identified glucopyranosyl and 6 glucopyranosyl as major terminal carbohydrate residues Nonpolar compounds were separated from polar components through solid phase extraction and analyzed by both reverse phase HPLC and LC MS methods Two nonpolar cytotoxic components oleandrin and its aglycone oleandrigenin were detected Quantitative analysis showed that the oleander extract contained oleandrin and oleandrigenin at concentrations of 2 5 and 4 4 μ g mg extract respectively Five proteins with molecular weights of 6 20 35 68 and 150 kD were also identified in the oleander extract although their functions remain unknown Cytotoxicity studies showed oleandrin to be a potent growth inhibitory compound against human melanoma BRO cells with an IC50 of 4 0 ng ml In the same test system the IC50 values for oleandrigenin and the complete oleander extract against human melanoma cells were 17 0 ng ml and 1 6 μg ml respectively This initial characterization and pharmacology research has served as a basis for quality control studies for the production and subsequent clinical Phase I trial of AnvirzelTM Composition and Preliminary Pharmacology Studies with Anvirzel An Extract of Nerium oleander Biochemical Pharmacology 62 4 2001 pp 469 472 Biochemical Pharmacology 62 4 2001 pp 469 472 Report Inhibition of export of fibroblast growth factor 2 FGF 2 from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component oleandrin Judith A Smitha Timothy Maddenb c Mary Vijjeswarapub Robert A Newmanb c a Division of Pharmacy University of Texas M D Anderson Cancer Center Houston TX 77030 USA b Pharmaceutical Development Center University of Texas M D Anderson Cancer Center Houston TX 77030 USA c Department of Experimental Therapeutics University of Texas M D Anderson Cancer Center Box 52 1515 Holcombe Blvd Houston TX 77030 USA Abstract AnvirzelTM is an extract of Nerium oleander currently undergoing Phase I clinical evaluation as a potential treatment for cancer Two of the active components of AnvirzelTM are the cardiac glycosides oleandrin and oleandrigenin Previous studies have demonstrated that in vitro cardiac glycosides may inhibit fibroblast growth factor 2 FGF 2 export through membrane interaction with the Na K ATPase pump In continuing research on the antitumor activity of this novel plant extract the relative abilities of oleandrin and oleandrigenin to inhibit FGF 2 export from two human prostate cancer cell lines DUl45 and PC3 were examined An ELISA assay was utilized to determine the FGF 2 concentration in the cell culture medium before and after exposure to cardiac glycosides or the parent extract material AnvirzelTM Both cell lines were exposed to non cytotoxic concentrations of oleandrin 0 05 and 0 1 ng mL for up to 72 hr Studies also were conducted with AnvirzelTM and ouabain Oleandrin 0 1 ng mL produced a 45 7 inhibition of FGF 2 release from PC3 cells and a 49 9 inhibition from DU145 cells Non cytotoxic concentrations 100 ng mL of AnvirzelTM produced a 51 9 and 30 8 inhibition of FGF 2 release respectively in the two cell lines The decrease in FGF 2 release from cells required continuous incubation for 48 72 hr shorter incubation times were not effective These results demonstrate that AnvirzelTM like oleandrin inhibited FGF 2 export in vitro from PC3 and DUI45 prostate cancer cells in a concentration and time dependent fashion and may therefore contribute to the antitumor activity of this novel treatment for cancer Inhibition of export of fibroblast growth factor 2 FGF 2 from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component oleandrin Anti Cancer Drugs 2000 11 pp 455 463 Anti Cancer Drugs 2000 11 pp 455 463 Report AnvirzeI an extract of Nerium oleander induces cell death in human but not murine mouse cancer cells Sen Pathak 1 2 Asha S Multani 1 Satya Narayan 3 Virendra Kumar 3 and Robert A Newman 4 Departments of 1 Cancer Biology and 2 Laboratory Medicine and 4 Pharmaceutical Development Center University of Texas MD Anderson Cancer Center Houston TX 77030 USA 3 Shands Cancer Center and Department of Anatomy and Cell Biology University of Florida Gainesville FL 32610 USA Anvirzel oleander extract is a novel antitumor compound extracted from a flowering plant N oleander belonging to the family Apocynaceae Anvirzel consists of several compounds including complex polysaccharides proteins and individual sugars It contains non water soluble compounds and two of these have been specifically identified by molecular weight and fragmentation characterization as Oleandrin and Oleandrigenin Newman et al unpublished observations These two compounds of Anvirzel and possibly a third one are cytotoxic In the present studies we examined the cytotoxicity of Anvirzel and Oleandrin on cancer cell lines of human murine and canine origin Our results from tests on cultures of two human prostate cancer cell lines PC 3M and C4 2 and a murine melanoma cell line K1735 X21 treated with Anvirzel and Oleandrin indicate several novel features i neither Anvirzel nor Oleandrin showed any cytotoxic effect on murine melanoma K1735 X21 cells ii when using even low drug concentrations human prostate cancer PC 3M cells showed significant susceptibility to cell killing iii the cell killing is apparently mediated through the loss of telomeric DNA followed by the arrest of cells in G2 M phase induction of endomitosis extensive DNA fragmentation reduced levels of TRF2 and finally cell death iv FACS analysis revealed induction of cell death in a dose and

    Original URL path: http://www.saludintegral.hn/anvirzel/publications (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - Credentials
    of Life Questionnaire Patient and Physician Information Patient Consents Patient Affirmation REORDER SUPPLIES Instructions info Payment REQUEST INFO Initial Inquiry Credentials Salud Integral holds the following certificates and trademarks Honduras Secretary of Health Registration Anvirzel Trademark Good Manufacturing Practices Certificate

    Original URL path: http://www.saludintegral.hn/anvirzel/credentials (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - Treatment overview and guidelines
    with current medical records for their use and information as long as he she continues on Anvirzel therapy Acceptance into a prescribed Anvirzel therapy regimen by the medical staff of Salud Integral S A and the commencement of that regimen by the patient constitutes an acceptance of this condition Provide Medical Records In order for our medical staff to be able to accurately determine acceptability and proper dosage patients will be required to submit their medical records to the offices of Salud Integral for review by our medical staff prior to being accepted for Anvirzel therapy Patients need to provide the completed Medical Overview Form and copies of their medical records that include physician report summaries of their current status and prognosis medical history evolution of disease and laboratory test results Blood Work results and interpretations of Biopsy Pathology CAT Scans MRI PET etc MEDICAL OVERVIEW MEDICAL RECORDS Provide Patient Information Patient must provide address and contact information physician information and Quality of Life questionnaire PATIENT PHYSICIAN INFO QUALITY OF LIFE QUESTIONNAIRE Personal Use Guidelines requirements Provide Patient Consent Patient must provide signed consent for Release of Medical Records Acknowledgment for Use of Records Condition of Participation and Consent to

    Original URL path: http://www.saludintegral.hn/treatment (2016-02-17)
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  • Salud Integral Distributor of AnvirzelTM - Provide Medical Records and Health Overview
    Blood Work results and interpretations of Biopsy Pathology CAT Scans MRI PET etc Best completed in Google Chrome or Firefox Browser you may get errors if viewed and completed in Internet Explorer Browser Patient Name Please enter the patient s name Email Please enter a valid email address Age Please enter the patient s age Weight Invalid Input Please state unit example 100 pounds Height Invalid Input Please state height unit example 5 feet 2 inches Sex Male Female Please make a selection Patient Address Please enter your complete address here Physician s Name Please enter the physician s name here Initial Diagnosis Please enter your initial diagnosis here Date of Diagnosis Please enter date of diagnosis Progression of the disease Please describe the progression of the disease Current Treatment Please describe your current treatment here Describe and provide the start date type dose and response to treatment Other Medical Conditions Please enter other medical conditions of patient here Current Medications Invalid Input Please list all medications you are currently taking including Medication name dosage and condition prescribed for Performance Status Please check only one 100 Normal no complaints no evidence of disease 90 Able to carry on normal activity

    Original URL path: http://www.saludintegral.hn/treatment/medical-overview (2016-02-17)
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